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ADAMS LAB
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PUBLICATIONS

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The landscape of targets and lead molecules for remyelination

2022
Nature Chemical Biology
Andrew V. Caprariello & Drew J. Adams

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Enhancers of Human and Rodent Oligodendrocyte Formation Predominantly Induce Cholesterol Precursor Accumulation

2022
ACS Chemical Biology
Joel L. Sax, Samantha N. Hershman, Zita Hubler, Dharmaraja Allimuthu, Matthew S. Elitt, Ilya Bederman, and Drew J. Adams

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ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models

2022
Nature Communications
Yuanyuan Zhao, Di Hu, Rihua Wang, Xiaoyan Sun, Philip Ropelewski, Zita Hubler, Kathleen Lundberg, Quanqiu Wang, Drew J. Adams, Rong Xu & Xin Qi
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Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation

2021
RSC Chemical Biology
Matthew J, Pleshinger,   Ryan M. Friedrich,   Zita Hubler,   Adrianna M. Rivera-León, Farrah Gao,   David Yan,   Joel L. Sax,   Ramya Srinivasan,   Ilya Bederman,   H. Elizabeth Shick,   Paul J. Tesar   Drew J. Adams

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Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease

2021
Nature Communications
Di Hu, Xiaoyan Sun, Anniefer Magpusao, Yuriy Fedorov, Matthew Thompson, Benlian Wang, Kathleen Lundberg, Drew J. Adams & Xin Qi
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Screening Reveals Sterol Derivatives with Pro-Differentiation, Pro-Survival, or Potent Cytotoxic Effects on Oligodendrocyte Progenitor Cells

2021
ACS Chemical Biology
Joel L. Sax, Zita Hubler, Dharmaraja Allimuthu, and Drew J. Adams

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Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation

2021
Cell Chemical Biology
Zita Hubler, Ryan M. Friedrich, Joel L. Sax, Dharmaraja Allimuthu, Farrah Gao, Adrianna M. Rivera-León, Matthew J. Pleshinger, Ilya Bederman, Drew J. Adams

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Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS

2020
Cell
Daniel C. Factor, Anna M. Barbeau, Kevin C. Allan, Lucille R. Hu, Mayur Madhavan, An T. Hoang, Kathryn E.A. Hazel, Parker A.Hall, Sagar Nisraiyya, Fadi J. Najm, Tyler E. Miller, Zachary S.Nevin, Robert T. Karl, Bruna R. Lima, Yanwei Song, Alexandra G. Sibert, Gursimran K. Dhillon, Christina Volsko, Cynthia F. Bartels, Drew J. Adams, Ranjan Dutta, Michael D. Gallagher, William Phu, Alexey Kozlenkov, Stella Dracheva, Peter C. Scacheri, Paul J. Tesar, Olivia Corradin

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Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers

2019
Nature Communications
Priyanka Gopal, Elif Irem Sarihan, Eui Kyu Chie, Gwendolyn Kuzmishin, Semihcan Doken, Nathan A. Pennell, Daniel P. Raymond, Sudish C. Murthy, Usman Ahmad, Siva Raja, Francisco Almeida, Sonali Sethi, Thomas R. Gildea, Craig D. Peacock, Drew J. Adams & Mohamed E. Abazeed

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Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma

2019
The Journal of Clinical Investigation
Ian Bayles, Malgorzata Krajewska, W. Dean Pontius, Alina Saiakhova, James J. Morrow, Cynthia Bartels, Jim Lu, Zachary J. Faber, Yuriy Fedorov, Ellen S. Hong, Jaret M. Karnuta, Brian Rubin, Drew J. Adams, Rani E. George, and Peter C. Scacheri
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Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP

2019
Cell Chemical Biology
Dharmaraja Allimuthu, Zita Hubler, Fadi J.Najm, Hong Tang, Ilya Bederman, William Seibel, Paul J. Tesar, Drew J. Adams
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Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease

2018
Stem Cell Reports
Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar
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Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

2018
Nature
Zita Hubler, Dharmaraja Allimuthu, Ilya Bederman, Matthew S. Elitt, Mayur Madhavan, Kevin C. Allan, H. Elizabeth Shick, Eric Garrison, Molly T. Karl, Daniel C. Factor, Zachary S. Nevin, Joel L. Sax, Matthew A. Thompson, Yuriy Fedorov, Jing Jin, William K. Wilson, Martin Giera, Franz Bracher, Robert H. Miller, Paul J. Tesar & Drew J. Adams
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Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor

2017
PLoS One
Olga Gorelenkova Miller, Kyle S. Cole, Corey C. Emerson, Dharmaraja Allimuthu, Marcin Golczak, Phoebe L. Stewart, Eranthie Weerapana, ​Drew J. Adams, John J. Mieyal
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2-Chloropropionamide As a Low-Reactivity Electrophile for Irreversible Small-Molecule Probe Identification

2017
ACS Chemical Biology
Dharmaraja Allimuthu and Drew J. Adams

Adams Lab

Case Western Reserve School of Medicine
drew.adams[at]case.edu

  • News
  • Science
  • PUBLICATIONS
  • Principal Investigator
  • Team
  • Fun
  • Support