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C646 degrades Exportin-1 to modulate p300 chromatin occupancy and function
2024 Cell Chemical Biology Yi Fan Chen, Atikur Rahman, Joel L. Sax, Matthew J. Atala-Pleshinger, Drew J. Adams |
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Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation
2024 Nature Chemical Biology Yi Fan Chen, Maryam Ghazala, Ryan M. Friedrich, Brittany A. Cordova, Frederick N. Petroze, Ramya Srinivasan, Kevin C. Allan, David F. Yan, Joel L. Sax, Kelley Carr, Suzanne L. Tomchuck, Yuriy Fedorov, Alex Y. Huang, Amar B. Desai & Drew J. Adams |
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Lipid-Restricted Culture Media Reveal Unexpected Cancer Cell Sensitivities
2024 ACS Chemical Biology Ralston B. Goldfarb, Matthew J. Atala Pleshinger, David F. Yan, and Drew J. Adams |
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The landscape of targets and lead molecules for remyelination
2022 Nature Chemical Biology Andrew V. Caprariello & Drew J. Adams |
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Enhancers of Human and Rodent Oligodendrocyte Formation Predominantly Induce Cholesterol Precursor Accumulation
2022 ACS Chemical Biology Joel L. Sax, Samantha N. Hershman, Zita Hubler, Dharmaraja Allimuthu, Matthew S. Elitt, Ilya Bederman, and Drew J. Adams |
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ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models
2022 Nature Communications Yuanyuan Zhao, Di Hu, Rihua Wang, Xiaoyan Sun, Philip Ropelewski, Zita Hubler, Kathleen Lundberg, Quanqiu Wang, Drew J. Adams, Rong Xu & Xin Qi |
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Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation
2021 RSC Chemical Biology Matthew J, Pleshinger, Ryan M. Friedrich, Zita Hubler, Adrianna M. Rivera-León, Farrah Gao, David Yan, Joel L. Sax, Ramya Srinivasan, Ilya Bederman, H. Elizabeth Shick, Paul J. Tesar Drew J. Adams |
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Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease
2021 Nature Communications Di Hu, Xiaoyan Sun, Anniefer Magpusao, Yuriy Fedorov, Matthew Thompson, Benlian Wang, Kathleen Lundberg, Drew J. Adams & Xin Qi |
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Screening Reveals Sterol Derivatives with Pro-Differentiation, Pro-Survival, or Potent Cytotoxic Effects on Oligodendrocyte Progenitor Cells
2021 ACS Chemical Biology Joel L. Sax, Zita Hubler, Dharmaraja Allimuthu, and Drew J. Adams |
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Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation
2021 Cell Chemical Biology Zita Hubler, Ryan M. Friedrich, Joel L. Sax, Dharmaraja Allimuthu, Farrah Gao, Adrianna M. Rivera-León, Matthew J. Pleshinger, Ilya Bederman, Drew J. Adams |
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Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS
2020 Cell Daniel C. Factor, Anna M. Barbeau, Kevin C. Allan, Lucille R. Hu, Mayur Madhavan, An T. Hoang, Kathryn E.A. Hazel, Parker A.Hall, Sagar Nisraiyya, Fadi J. Najm, Tyler E. Miller, Zachary S.Nevin, Robert T. Karl, Bruna R. Lima, Yanwei Song, Alexandra G. Sibert, Gursimran K. Dhillon, Christina Volsko, Cynthia F. Bartels, Drew J. Adams, Ranjan Dutta, Michael D. Gallagher, William Phu, Alexey Kozlenkov, Stella Dracheva, Peter C. Scacheri, Paul J. Tesar, Olivia Corradin |
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Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
2019 Nature Communications Priyanka Gopal, Elif Irem Sarihan, Eui Kyu Chie, Gwendolyn Kuzmishin, Semihcan Doken, Nathan A. Pennell, Daniel P. Raymond, Sudish C. Murthy, Usman Ahmad, Siva Raja, Francisco Almeida, Sonali Sethi, Thomas R. Gildea, Craig D. Peacock, Drew J. Adams & Mohamed E. Abazeed |
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Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma
2019 The Journal of Clinical Investigation Ian Bayles, Malgorzata Krajewska, W. Dean Pontius, Alina Saiakhova, James J. Morrow, Cynthia Bartels, Jim Lu, Zachary J. Faber, Yuriy Fedorov, Ellen S. Hong, Jaret M. Karnuta, Brian Rubin, Drew J. Adams, Rani E. George, and Peter C. Scacheri |
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Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP
2019 Cell Chemical Biology Dharmaraja Allimuthu, Zita Hubler, Fadi J.Najm, Hong Tang, Ilya Bederman, William Seibel, Paul J. Tesar, Drew J. Adams |
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Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease
2018 Stem Cell Reports Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar |
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Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination
2018 Nature Zita Hubler, Dharmaraja Allimuthu, Ilya Bederman, Matthew S. Elitt, Mayur Madhavan, Kevin C. Allan, H. Elizabeth Shick, Eric Garrison, Molly T. Karl, Daniel C. Factor, Zachary S. Nevin, Joel L. Sax, Matthew A. Thompson, Yuriy Fedorov, Jing Jin, William K. Wilson, Martin Giera, Franz Bracher, Robert H. Miller, Paul J. Tesar & Drew J. Adams |
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Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor
2017 PLoS One Olga Gorelenkova Miller, Kyle S. Cole, Corey C. Emerson, Dharmaraja Allimuthu, Marcin Golczak, Phoebe L. Stewart, Eranthie Weerapana, Drew J. Adams, John J. Mieyal |
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2-Chloropropionamide As a Low-Reactivity Electrophile for Irreversible Small-Molecule Probe Identification
2017 ACS Chemical Biology Dharmaraja Allimuthu and Drew J. Adams |