Lab News
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Drew's review paper is the cover of Nature Chemical Biology!
In this review, Drew et al. discusses the landscape of research surrounding remyelination and the associated therapeutic strategies. Photo credz to our longtime collaborator Paul Tesar! Check out the perspective here! August 2022 |
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Joel's Paper is Published in ACS Chemical Biology!
Joel et al. validates sterol accumulation as the dominant driver of small molecule-mediated oligodendrocyte differentiation. Check out the paper here! August 2022 |
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Yi Fan is appointed to the Functional Genomics Training Grant
This will support Yi Fan's graduate training for two years following the conclusion of his Harrington Scholar award. July 2022 |
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Zita wins the Martin Wahl Memorial Fund Award
This award is given to a graduating MD/PhD student who demonstrates exceptional research accomplishment and independence. May 2022 |
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Zita matches to Barnes-Jewish Hospital!
Congratulations to Zita for matching into the clinical pathology program at Barnes-Jewish Hospital / Washington University in St. Louis for her physician-scientist training. We're excited to see what you'll accomplish from here on out! March 2022 |
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Yi Fan receives 3rd Place at the 3 Minute Thesis Competition
For delivering an impassioned explanation of his thesis work, Yi Fan wins $1000 in cash prize to be lost in questionable cryptocurrency investments. February 2022 |
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Adams Lab Wins Awards at the 44th Annual Biomedical Graduate Student Symposium
Matthew wins a best poster award for his group, and Yi Fan was selected for an oral presentation and wins second place for that result. Although Yi Fan considers it a loss because the organizers spelled his name wrong. November 2021 |
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Matthew wins NRSA F31 Fellowship from the NIH
Matthew is awarded a competitive fellowship from the NIH for his predoctoral training! November 2021 |
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Matthew's Target Validation is published in RSC Chemical Biology!
Matthew et al. combined multiple approaches to evaluate SC4MOL and HSD17B7 as viable targets in remyelinating therapies, expanding on the model proposed by the Adams lab where changing 8,9 unsaturated sterol landscapes causes remyelination. Check out the paper here! October 2021 |
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Drew discusses remyelinating therapies at the American Society for Neurochemistry Annual Meeting
In his presentation, Drew discusses how our lab arrived at the key insight of sterol landscape modulation as a unifying mechanism for small molecules to enhance remyelination. This work was pioneered by Zita in close collaboration with our colleague Paul Tesar. Check out the presentation here. July 2021 |
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Joel's Sterol Screen is published in ACS Chemical Biology!
Joel's small molecule screening efforts identified sterol derivatives that hint at how the physiology of oligodendrocyte progenitors can be modulated to achieve divergent outcomes. Check out the paper here! July 2021 |
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Drew Adams promoted to Associate Professor!
Congratulations to Drew on his promotion to Associate Professor with tenure! July 2021 
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Zita recognized with the Marian Kies Memorial Award!
This award from the American Society for Neurochemistry is given to one graduate student in the nation who conducted exceptional research in neuroscience during graduate training - an appropriate honor that highlights how Zita's work have transformed our understanding of how we can harness the regenerative potential of oligodendrocytes for therapeutic impact. June 2021 |
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Adrianna moves on to graduate training!
Adrianna will join the Medical Scientist Training Program at the University of Minnesota for her physician-scientist training! Well deserved! And we wish you all the best! May 2021 |
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Zita wins the Doctoral Excellence Award!
The Doctoral Excellence Award at Case Western Reserve University is given to at most one graduate student per department who demonstrated exemplary research and scholarship during graduate training - a fitting honor for Zita's contributions to the Adams lab (but let's also be real - we all expected this). April 2021 |
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Zita's 3rd Paper is Published in Cell Chemical Biology!
"Modulation of lanosterol synthase drives 24,25-epoxycholesterol synthesis and oligodendrocyte formation" forms the final part of Zita's prolific research record, expanding on our model of modulating sterol landscapes to drive oligodendrocyte differentiation. Check out her paper here! Feb 2021 |
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Ramya joins the lab!
Ramya, a new postdoctoral fellow, will join the lab to provide critical synthetic chemistry support that makes our research more impactful. We're happy to have you! Feb. 2021 |
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David joins the lab for full-time!
David is a current undergraduate student who has provided important chemistry support for the projects in the lab. He will now join us in a full-time capacity. Nov. 2020 |
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Adrianna wins best poster award
Adrianna wins the best poster award in her poster group at the 2020 Biomedical Graduate Student Symposium. Awesome job! Nov. 2020 |
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Ryan graduates!
Ryan has officially grown up and will be leaving the lab to move on to a much less exciting career in industry! We will remember him fondly for all the times we requested express delivery of our favorite new compounds over to biology realm. Congrats to Ryan! Nov. 2020 |
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Welcome Maryam!
Maryam Ghazala joins the lab as a research technician alongside Samantha! Great to have you on board! Oct. 2020 |
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Welcome Samantha!
Samantha Hershman joins the lab as a research technician - we're happy to have you!
Aug. 2020 |
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Yi Fan received the Harrington-MSTP Scholar Award from the Harrington Discovery Institute
This two-year grant will support his chemical biology research to understand drug mechanisms. He will also work with the Harrington's therapeutics development team for translation of that research.
May 2020 |
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Matthew has been re-appointed for support by the Molecular Therapeutics Training Program (MTTP) Training Grant!
This grant will support him for one year in the lab during his graduate studies.
May 2020 |
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Zita defends her thesis!
Congratulations to Dr. Hubler for successfully defending her thesis and becoming the first graduate from the Adams Lab!
April 2020 |
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Adams Lab Awarded NIH R01This grant will support our work to understand how we can alter sterol signaling in order to promote remyelination in patients with demyelinating diseases. Many congrats to Drew!
April 2020 |
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Adams Lab Receives Support from the Dr. Ralph and Marian Falk Research Trust
This grant, in close collaboration with associate professor Xin Qi in the department of physiology, will accelerate drug discovery efforts to enhance mitochondrial function and survival in Huntington's Disease.
January 2020 |
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Adrianna and Matthew Present at the Biomedical Graduate Student SymposiumAdriana and Matthew (and Zita) represented the cutting edge research of the Adams Lab at the BGSS. Go team!
October 2019 |
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Drew wins the Folch Pi Prize of the American Society for NeurochemistryCongrats to Drew on being honored as the 2019 recipient of the Folch Pi Travel Prize! This award is given by the American Society for Neurochemistry to honor a junior investigator with extraordinary promise in neurochemistry. The award is named after Jordi Folch Pi, the founding President of ASN who, fittingly enough, pioneered methods for extracting sterols and other lipids from the brain.
August 2019 |
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Convelo enters collaboration with Genentech
Congrats to Convelo Therapeutics, co-founded by Drew and colleague Paul Tesar, on entering into a collaboration and option-to-acquire deal with Genentech! This deal allows Convelo to accelerate its efforts to identify the first remyelinating therapeutics.
July 2019 |
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Welcome Yi Fan and Adrianna!We have had two new member join the lab over the summer! Yi Fan is an MSTP student who will be joining full time in May of 2020. Adrianna will be working in the lab as part of the PREP program for two years. Welcome to the team!
July 2019 |
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The Adams Lab received a grant from the Mathers Foundation!This multi-year award is allowing us to accelerate our work to understand how altered sterol signaling may impact diseases of myelin. We’re hugely grateful for the support of the Foundation and all our supporters!
June 2019 |
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Matthew has been selected for support by Molecular Therapeutics Training Program (MTTP) Training Grant!This grant will support him for one year in the lab during his graduate studies.
May 2019 |
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Farrah is awarded the Provost Summer Undergraduate Research Grant!This grant will support her research over the summer in our lab. Congratulations Farrah!
April 2019 |
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Matthew was chosen for the Berg-Wood graduate training fellowship!This fellowship is named after Harland G Wood and Paul Berg. It will support Matthew's training and some of his ongoing work in the lab. Great work Matthew!
March 2019 |
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Dharma and Zita's paper is published in Cell Chemical Biology!"Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP" Cell Chemical Biology, 2019, https://doi.org/10.1016/j.chembiol.2019.01.004
14 February 2019 |
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The Adams Lab received a Pilot Research Grant from the National Multiple Sclerosis Society!This award is helping us generate new data to understand how sterol signaling contributes to myelin repair in MS.
January 2019 |
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Welcome Matthew!Matthew Pleshinger has joined the lab as a graduate student in the department of pharmacology!
December 2018 |
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Dharma departs the Adams lab to establish the Dharmaraja Lab at IITK!We are thrilled to announce that Dharma has accepted a faculty position at Indian Institute of Technology Kanpur in the department of Chemistry! Best of luck to Dharma!
November 2018 |
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Zita wins first place for her oral presentation at the Biomedical Graduate Student Symposium
25 October 2018 |
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Zita and Dharma's paper is published in Nature!"Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination" Nature, 2018, http://dx.doi.org/10.1038/s41586-018-0360-3
Our work provides a new roadmap for promoting myelin repair in multiple sclerosis and other diseases. Huge thanks to everyone who helped us out along the way, whether across the hall (that's you, Tesar Lab) or across the globe! Check out the press release for more info: http://casemed.case.edu/cwrumed360/news-releases/release.cfm?news_id=1375&news_category=8 25 July 2018 |
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Drew and Paul co-found Convelo Therapeutics!Convelo Therapeutics, Inc. disclosed today that it has raised $7.8 million to develop new therapeutics for diseases of myelin. Co-founded by Drew and close collaborator Paul Tesar, Convelo is located in Cleveland and led by a team of Boston-based biotech pioneers: CEO Derrick Rossi (co-founder of Moderna, Intellia, and Magenta) and Chief Development Officer Steve Landau (Shape, Tensha).
Check out the press release for more details! https://www.businesswire.com/news/home/20180725005491/en/Convelo-Therapeutics-Develop-New-Regenerative-Medicines-Neurological 25 July 2018 |
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Drew is now the Thomas F. Peterson, Jr. Professor of Cancer and Energy Research!At a ceremony led by Dean Davis, Drew was honored as the Thomas F. Peterson, Jr. Professor of Cancer and Energy Research. Tom's generous support has accelerated the research of several Case Western Reserve scientists, including two endowed chairs, and it was a pleasure to have him join the ceremony. Thanks Tom!
28 June 2018 |
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Zita wins Ruth L. Kirschstein NRSA F30 Fellowship!Zita Hubler was awarded an individual research fellowship for her work investigating the mechanism of action of small molecules which enhance oligodendrocyte formation. This fellowship will provide her with funding to enhance her training as a future physician-scientist.
7 June 2018 |
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Drew wins the CWRU Jackson Award for undergraduate mentoringCase Western Reserve University President Barbara Snyder visited the Genetics Department today to honor Drew with the J. Bruce Jackson, MD Award for Excellence in Undergraduate Mentoring. A very cool honor for a junior faculty member -- nice apple, too!
"The Jackson Award celebrates two faculty annually who have guided a student in their academic and career paths; fostered the student’s long-term personal development; challenged the student to reflect, explore and grow as an individual; and supported and/or facilitated the student’s goals and life choices." 1 May 2018 |
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Matt is awarded an ACS Organic Division SURF Fellowship!Following close on the heels of his Goldwater Scholarship, Matt Thompson has now been awarded a competitive fellowship from the American Chemical Society to support his research this summer. Amazing! Drew claims he won the same fellowship as an undergrad, but it must've pre-dated the internet because we can't find any record of it...
5 April 2018 |
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Matt wins the Goldwater Scholarship!Wow! Matt won a Goldwater Scholarship! "The most prestigious undergraduate scholarship in the natural sciences, mathematics, and engineering in America." A truly well-deserved honor. We've posted the goofiest picture available to keep you humble.
4 March 2018 |
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Welcome Farrah!Farrah Gao has joined the lab as an undergraduate researcher - welcome!
4 March 2018 |
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Welcome Joel!Joel Sax has committed to joining the lab for the PhD phase of his MD/PhD training. Joel previously did chemical biology research as an undergraduate at UC-Berkeley. Welcome Joel!
26 Feb 2018 |
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Ryan joins the lab!Ryan is joining the lab as a postdoctoral fellow and will work closely with the Small Molecule Drug Development Core. He completed his PhD at the University of Iowa in organic chemistry.
14 Feb 2018 |
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Dharma’s paper published in ACS Chemical Biology!This work identified a protein disulfide isomerase (PDI) targeting covalent chemical probe featuring a novel 2-choloroproipionamide electrophile, and this probe is the least reactive irreversible inhibitor of PDI reported to date.
14 June 2017 |